Can Miravil 50 mg/day (taken in the morning) and Plaquenil 200 mg/day (taken in the evening) be used at the same time? The psychiatrist prescribed sertraline and the rheumatologist prescribed hydroxychloroquine, but none of the doctors knew how or if the two interacted. Is it safe to use these drugs together for a long period of time? I would like to add that I am a woman, I am 34 years old, I have a healthy liver, kidneys and heart, I do not have addictions or allergies to any medications, I suffer chronically from atopic dermatitis (here I use various steroids in ointments and protopic ointment), hypothyroidism and Hashimoto's (I use Letrox at a dose of 100 microg/day), irritable bowel syndrome (I am not currently taking anything here), undifferentiated connective tissue disease (psoriatic arthritis or lupus and probably antiphospholipid syndrome, I'm still being diagnosed - here I'm taking Aglan 15 mg/day for joint pain and now I'm supposed to start Plaquenil) and anxiety disorders and depression (here sertraline). Thank you in advance for your reply.