Hello. I have been taking Setaloft for half a year. At first I took a dose of 25mg for a week, then 50, after some time 75mg. For the first 3 weeks I felt tragic. All the symptoms associated with depression did not pass and even worsened. After that time, it was only better. I gained energy, willingness to live and finally stopped feeling tired and sleeping during the day. After a few months, it was as if the drug had stopped working and all the symptoms associated with depression returned. The doctor told me to increase the dose to 100mg, so I did it. I take Setaloft in a dose of 100mg for the third week, I have already gained some energy, but this is not what I expected. I still feel tired a lot and sleep a few hours a day. I also often feel sadness and apathy and nothing pleases me. I also still have fears in my stomach. Will this pass over time, or does the drug no longer work for me? I'm mainly talking about energy and general desire to live, so that I can enjoy life again and be happy. At what dose of Setaloft should I stay so as not to feel tired and discouraged? Perhaps 100mg, that's too much. Maybe with a smaller dose I will feel better. I have always been a person full of energy, positive about the world and people, loving life, and today I feel like a wreck of a man who does not have the strength to get out of bed in the morning and do anything. I don't feel like interacting with people, and I've always been a sociable person who loved people very much, today I don't care. In general, I feel at times as if I do not have feelings now, and since I was a child I have been a very sensitive person. I don't understand what happened to me. I feel really bad and I would like to change it. Is there hope that since the drug worked before, it will work now, it only takes time, because I increased the dose? However, can he reduce the dose of the drug or change to another one? Please reply. Yours sincerely.