There are no duloxetine tablets of less than 30 mg in Poland. Since these are capsules, is it possible to take 30 mg of duloxetine every other day so that the concentration of the drug is lower than the 30 mg..? What to do if the patient wants to take less than 30 mg of duloxetine, e.g. 20 mg or 15 mg? Is it possible to do this if these capsules cannot be divided?
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Ewa Pilch Pharmacist, Editor
53 days ago
If you have been recommended to use lower doses than 30 mg, you should consult your doctor again, who should prescribe a detailed schedule of use of the recommended preparation. The patient should not reduce the prescribed dose or modify a specific treatment regimen on their own. Treatment with lower doses of duloxetine than 30 mg should be done under the close supervision of the doctor and according to the doctor's recommendations (in which case, the doctor will determine, for example, how to use individual capsules/tablets).
You can also take advantage of a paid teleconsultation arranged e.g. via the Gdziepolek.pl portal:
https://www.gdziepolek.pl/telekonsultacja
Duloxetine is available not only in capsule form, but also in the form of enteral tablets (indivisible). Doses lower than 30 mg are not available due to the lack of therapeutic efficacy demonstrated in studies.
On the other hand, studies published, for example, in the Journal of Psychiatric Research indicate that duloxetine is effective in the treatment of the acute depressive phase at a dose of 40-60 mg/day. However, administering the preparation at a dose of 40 mg (2 x 20 mg regimen) is significantly less effective than administering a dose of 60 mg once a day. In the absence of effects, it is recommended to increase the dose even to 120 mg per day.
Lower doses, i.e. 30 mg, are the starting dose in the treatment of anxiety disorders. The usual maintenance dose is 60 mg.
Once the appropriate therapeutic effects have been achieved, treatment should be maintained for at least a few months.
I attach a link with a list of duloxetine products available in pharmacies:
https://www.gdziepolek.pl/substancje/duloksetyna
I encourage you to read the additional materials that may be useful:
https://www.gdziepolek.pl/artykuly/depresja
https://www.gdziepolek.pl/artykuly/jak-poradzic-sobie-z-nerwica