Saffron can indeed improve mood and well-being. It has been shown to increase the concentration of neurotransmitters in the brain, m.in. serotonin. However, this effect is similar to that of duloxetine, which increases the risk of the so-called serotonin syndrome (a rare side effect). Symptoms include: excessive satisfaction, drowsiness, anxiety, impaired motor coordination, muscle stiffness, fever, sweating, and a feeling of alcohol intoxication. Therefore, it is best to consult the desire to use saffron with your attending physician and discuss with him the observed ailments related to the depressed mood. Perhaps the changes in well-being are related to the duloxetine used?

The medications prescribed by the doctor, i.e. duloxetine and lamotrigine (Lamitrin), do not interact with each other.

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