Such a combination should be used with great caution.

Emanera may increase the risk of side effects of methotrexate (Metex), leading to m.in decreased white, red and platelet counts, liver and kidney damage. The addition of Pylera, which contains, m.in, tetracycline, increases the risk of this type of symptoms.

If you experience weakness m.in, nausea, vomiting, abdominal pain (especially in the right side), yellowing of the skin, swelling, decreased urine or other worrying symptoms, consult your doctor urgently.

If you notice any side effects, you should report them to your doctor, who will decide what to do next.
You can find out why you should report adverse drug reactions here:

https://www.gdziepolek.pl/artykuly/jak-i-dlaczego-zglaszac-dzialania-niepozadane

If you do not have the opportunity to consult your doctor, you can use the teleconsultation here:

https://www.gdziepolek.pl/telekonsultacja

I've attached links to helpful posts:

https://www.gdziepolek.pl/artykuly/leki-immunosupresyjne-obnizajace-odpornosc

https://www.gdziepolek.pl/kategorie/leki-na-helicobacter-pylori

Here you can check the availability of these medicines in pharmacies and make a reservation:

https://www.gdziepolek.pl/produkty/26933/emanera-kapsulki/apteki

https://www.gdziepolek.pl/produkty/48562/metex-iniekcja/apteki

https://www.gdziepolek.pl/produkty/65474/pylera-kapsulki/apteki