What is the difference between Belara and Vixpo in terms of gestagen? I know that Belara has a higher dose of ethinyl estradiol, but these preparations contain different gestagens and how do they differ? Which has a greater antiandrogenic effect and which can cause what side effects?
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Olga Sierpniowska Pharmacist
4 years ago
Belara contains 0.03 mg ethinylestradiol and 2 mg chlormadine acetate. The drug is used in a 21+7 regimen. Vixpo contains 0.02 mg ethinyl estradiol and 3 mg drospirenone. The drug is taken in a 24+4 scheme. Vixpo therefore has a lower daily dose of estrogen, but it should be noted that it is used for a larger number of days a month belara thread. Both chlormadinone acetate (CMA) and drospirenone antagonize androgen receptors. This means that they can have a beneficial effect on the appearance of the skin, reduce the symptoms of acne, oiliness and excessive hair. Their potency in this direction is comparable. On the other hand, cyproterone acetate has a stronger anti-orrogenic effect. CMA shows weak agonism towards glucocorticosteroid receptors, and drospirenone has no activity in this direction. A significant difference occurs in reaction with mineralocorticosteroid receptors. CMA has no activity in their direction, and drospirenone antagonizes them - thanks to this, it prevents water retention, which can translate into an "anti-edematous" effect or causing that the effect of tissue swelling will not occur. From the patient's point of view, this may mean fewer problems with the side effects of the pills, such as weight gain due to water retention or breast tenderness. Any medication may or may not cause side effects. All of them are described in the leaflet, which does not mean that everyone will experience: https://www.gdziepolek.pl/produkty/9841/belara-tabletki-powlekane/ulotka/115372 https://www.gdziepolek.pl/produkty/83747/vixpo-tabletki-powlekane/ulotka/185344 I attach additional information: https://www.gdziepolek.pl/artykuly/czy-bac-sie-dzialan-niepozadanych-lekow