Can combining Opipramol with Mysimba cause dangerous side effects such as seizures?

Yes, such a combination of drugs requires caution.

Mysimba (bupropion + naltrexone) may lower the seizure threshold in some people, i.e. increase the risk of seizures. Opipramol itself is not a typical anticonvulsant or strong convulsant drug, but it does act on the central nervous system and may potentiate some of the side effects of psychotropic drugs.

In this situation, the risk must be assessed individually – especially if the patient has a history of epilepsy, head injuries, eating disorders (bulimia, anorexia), alcohol abuse or sudden alcohol withdrawal. The "seizures" you are asking about are most often related to seizures – and here Mysimba has a clear warning.

In practice: such a combination is not automatically prohibited, but should only be turned on by a doctor who knows your neurological and psychiatric history and risks.

If you need more personalized advice, you can use the teleconsultation here:

https://www.gdziepolek.pl/telekonsultacja/

Through Gdziepolki it is possible to book medicines in a selected pharmacy in Polish:

https://www.gdziepolek.pl/produkty/88259/mysimba-tabletki-o-przedluzonym-uwalnianiu/apteki

https://www.gdziepolek.pl/produkty/63423/pramolan-tabletki-powlekane/apteki

I attach additional information that may be helpful:

https://www.gdziepolek.pl/artykuly/10-najczestszych-bledow-w-przyjmowaniu-lekow

https://www.gdziepolek.pl/artykuly/czy-przyjmowanie-kilku-lekow-jednoczesnie-jest-bezpieczne

https://www.gdziepolek.pl/artykuly/czy-mozna-laczyc-leki-ze-soba