Can itching and nausea persist for about two weeks after Palexia withdrawal?

Yes, it is possible, although these symptoms should gradually fade away.

Palexia (tapentadol) is a powerful opioid analgesic that directly affects receptors in the nervous system. Itching and nausea are some of the most common side effects of this group of drugs; They result, m.in, from the release of histamine and stimulation of the emetic center in the brain.

Although the drug itself is removed from the body relatively quickly (usually within 2-3 days), the reorganization of receptors in the nervous system after a month of treatment may take longer. In some patients, receptor hypersensitivity may persist for 1–2 weeks after discontinuation, especially if the body has reacted strongly to the substance.

However, pay attention to whether these symptoms are definitely getting worse – if their intensity persists for the next few days or a rash occurs, this may suggest another cause (e.g. an allergic reaction or liver irritation) and require basic blood tests (e.g. liver tests).

If you need more personalized advice, you can use the teleconsultation here:

https://www.gdziepolek.pl/telekonsultacja/

The advice is held in Polish.

You can check where you can buy Palexia in Poland here:

https://www.gdziepolek.pl/produkty/87187/palexia-retard-tabletki-o-przedluzonym-uwalnianiu/apteki

For more information:

https://www.gdziepolek.pl/artykuly/jakie-leki-przeciwbolowe-stosowac