Hello, I take Vixpo contraceptive pills. Can drinking grapefruit juice 2 hours after taking the tablet affect the effectiveness of the tablets and weaken them?
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Joanna Dunajska Pharmacist
3 years ago
I enclose an excerpt from our article, why grapefruit juice with hormonal contraception should not be used, which explains the answers to your questions: "When using hormonal contraception, you should not consume dietary supplements based on grapefruit extract (e.g. Citrosept Organic) and drink tablets with citrus juices (e.g. grapefruit, orange). The ingredients contained in them inhibit the activity of the cytochrome P450 isoenzyme 3A4, which is responsible for the metabolism of estradiol – a component of two-component contraceptives. In short, the liver will be "busy" with the decomposition of juice, not tablets. However, this will not lead to a decrease in their effectiveness, but may increase the risk of side effects (e.g. vomiting or diarrhea), which may only reduce the effectiveness of the tablets. Birth control pills are best washed down with still water." https://www.gdziepolek.pl/artykuly/jakie-leki-oslabiaja-skutecznosc-antykoncepcji