Such a combination should only be used after consultation with a doctor and for the shortest possible time.
If you observe any disturbing symptoms, you should consult a doctor.

Combining these drugs increases the risk of methotrexate side effects, especially a decrease in the number of white blood cells, red blood cells and platelets, liver and kidney damage. Especially with long-term therapy.

In the case of observing m.in weakness, nausea, vomiting, abdominal pain (especially in the right side), yellowing of the skin, swelling, reduced urine, bleeding (e.g. from the nose), tarry stool, etc. You should consult your doctor as soon as possible.

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