No significant interactions have been described between Dutilox and antiallergic medicines. There are no contraindications to the concomitant, short-term use of Xyzal, Zyrtec or Hitaxa together with Dutilox. Please note, however, that antihistamines (components of antiallergic drugs) may aggravate drowsiness and sedative effects that accompany the use of antidepressants. If you decide to take allergy medicines for a long time together with Dutilox, you should contact your doctor to determine the safe course of dosage. Yes, to minimize the risk of side effects. I enclose a link to a helpful entry: https://www.gdziepolek.pl/artykuly/leki-przeciwhistaminowe When it comes to combining Dutilox with food, you will find information in a similar post on the forum: https://www.gdziepolek.pl/opinie-i-pytania/13219/dutilox-o-jakiej-porze-dnia-stosowac-dutilox-i-czy-nalezy-przyjmowac-go-razem-z-posilkiem