Is it possible that adding Bupropion to Brintellix makes my hands shake and I can't sleep?

Last year I had a severe depression. Mirtazapine would have worked well as an AD at the beginning, but would have been heavily sedated. I needed up to 14 hours of sleep and was still tired. In addition, I had a desire to eat to the power of 10... The doctor switched me to escitalopram, which we increased to 15mg. In the beginning I had the typical side effects (dry mouth, restlessness, nausea, abnormal dreams, loss of libido, I could no longer feel my clitoris and there was no longer any talk of an orgasm). After 2 or 3 months I was able to work again. About 8 months later we tapered it off again. The main reason: libido.
With psychological support, less than two months passed, I really fell into the hole again. I was diagnosed with severe depression and I took Wellbutrin 150mg at my own request. (I am myself dipl. nurse and know a little about it). Against the restlessness I was accompanied with Quetiapine, Relaxan and Redormin. The 150mg was absolutely not enough, I became suicidal about 1 month after 1st intake and had to go to the acute clinic. They tried to increase the Wellbutrin to 300mg (note, I'm only 48 kg. In the time with Wellbutrin I lost 6kg within 2 months). Wellbutrin 300mg was really too much for me with my symptoms. The strong inner restlessness, a resting heart rate of 120 and the strong nausea/vomiting was not suitable. I developed panic attacks, was only crying, vomiting and a "small pile of misery". So I left the clinic again with 150mg, which went well for a short time, in the second week I got into the hole again so badly that I was admitted from the acute again. My pronounced morning low was no longer bearable, despite listlessness, listlessness an extreme restlessness and nausea. This time I came to another psychiatrist in the acute ward. He left various decisions to me. And one of them was to combine Wellbutrin 150mg with Brintellix, which I decided to do. We started with 5mg to sneak in. On the 1st day I didn't notice anything new (the usual restlessness, nausea and depri symptoms). From the 2nd day it started. Strong tremors, severe crying fits, insurmountable palpitations, gushing vomiting and hyperventilation. But this time I was convinced to go through with it. At night 50mg quetiapine and hardly slept, the heart asen drove me crazy. On the 3rd day, the same thing from the beginning. A psychiatrist worked with me (despite my lack of concentration) to develop skills that I can use. Since nothing helped, we decided on Quetiapine 50mg and Temesta ex 1mg. I slept for 3 hours in the afternoon and then I got up like a new born. And from that point on, things went uphill for me. It took time and the Brintellix is adjusted for me according to the symptoms. On the 5th day I was already back on the inline skating outside in the afternoon. The whole thing took 3 months, with the sneaking of Brintellix only bringing the improvement. I hope that this may also be the case for you.