Propranolol and Amiodarone are prescription medicines and you should follow your doctor's dosing instructions when using them. If you have not been informed about the time interval in which to take medicines, it is worth consulting your doctor again. In my opinion, it is worth keeping about 3-4 hours between taking these drugs. Severe sinus bradycardia may occur in patients taking Amiodarone and Propranolol concomitantly. Unfortunately, Amiodarone has a very long half-life (about 50 days), i.e. it stays in the body for a very long time after admission, so interactions can occur even after a few hours break. I enclose materials that may be useful: https://www.gdziepolek.pl/artykuly/czy-przyjmowanie-kilku-lekow-jednoczesnie-jest-bezpieczne