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Małgosia  (Anonymous, 37.31.48.) Warszawa 8 months ago

Does memantine taken 2 times a day at a dose of 10 mg work differently than once a day at a dose of 20 mg?
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Good morning
Does memantine taken 2 times a day at a dose of 10mg work differently than memantine taken once a day at a dose of 20mg. Are the effects of treatment the same in both cases, or maybe memantine at a dose of 20mg is more harmful to the digestive system.

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Angelika Talar-Śpionek

Angelika Talar-Śpionek Pharmacist, Editor

8 months ago

The therapeutic effect in both cases will be similar.

Taking 2×10 mg may be milder on the digestive system and reduce the risk of dizziness or drowsiness, as the maximum concentration after each dose is slightly lower.

Memantine has a long half-life (about 60–80 hours), which means that it persists in the body for several days. Thanks to this, it can be effectively taken once a day, without losing its therapeutic effect.

In some patients, especially those with more sensitive or gastrointestinal diseases, dose splitting may improve tolerability, reducing the risk of gastrointestinal side effects. Nevertheless, as I mentioned, the therapeutic effect in both cases will be the same.

According to the Safety Data Sheet, the manufacturer recommends taking the drug once a day, at a fixed time.

Check availability and book here:

https://www.gdziepolek.pl/produkty/48031/memantine-accord-tabletki-powlekane/apteki

Answer appreciated:
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