Is it possible to give in one day drugs Posela and Pyrantelum?

Ivermectin and pyrantel are better to dose in the following days, because their combination may cause too strong a herx effect. Only when the first course of treatment has not proved fully effective, then take both drugs at the same time. But also carefully, in smaller than suggested doses. Ivermectin can be enhanced by combining with zentel albendazole, these drugs act on each other synergistically, mutually enhance each other's action.