Is it normal for nodules to be felt at the Saxendy application site?

This can happen, but the drug should be administered subcutaneously in such a way as not to cause the formation of "nodules" or "guli". Perhaps the drug has been or has been administered too shallowly for a long time. In this situation, you can use needles with a length of 8 mm, e.g. https://www.gdziepolek.pl/produkty/48855/igly-do-penow-bd-micro-fine-plus-igla/apteki?pvid=258011#internetowe if shorter ones were previously used. It may also be a matter of incorrect use of these shorter needles (too shallow puncture). In addition, I would like to remind you to change the place of administration of the drug in addition to each change of the needle, do not give the drug to the same place all the time.