Will the swelling after administration of Depo-medrol disappear?

One of the possible reactions of the body to the local administration of Depo-medrol is swelling and pain at the injection site. Probably the symptoms will disappear within a few / several days, but this is an individual matter for each patient. If, however, the swelling persists, additional symptoms will appear - e.g. purulent effusion, severe pain, redness, you should see a doctor. I enclose an article that may be of interest: https://www.gdziepolek.pl/kategorie/leki-na-choroby-zwyrodnieniowe-stawow