If I took Apo-Napro 250mg in the morning, can I take Kostarox 60mg for the night?

It is inadvisable to combine NSAIDs with each other due to the increased risk of side effects, and at the same time does not increase the therapeutic effect on the patient. According to current medical literature, taking up to two different NSAIDs increases the risk of kidney or liver damage by as much as seven times. Due to the fact that Apo-Napro and Kostarox are prescription drugs, therefore the legitimacy and dosage regimen in therapy is determined by the doctor. Do not use these preparations without consulting a doctor. Both drugs also have a long-lasting effect in the body, so even a time interval of about 12 hours can have a negative impact on health. The maximum concentration of Apo-Napro in the blood plasma occurs 2-4 hours. The half-life is 12-15 hours, and the equilibrium state is reached within three days of the start of use. The half-life of Kostarox is about 22 hours. Steady-state concentration is reached within 7 days. These drugs can only be taken together if they have been prescribed by one doctor, or if the doctors prescribing these preparations have been informed about what other medicines the patient is already taking. I also encourage you to read the article: https://www.gdziepolek.pl/artykuly/czy-przyjmowanie-kilku-lekow-jednoczesnie-jest-bezpieczne https://www.gdziepolek.pl/artykuly/czy-mozna-laczyc-leki-ze-soba